Chemotherapy
drugs reduce quality of life often causing acute and delayed central
side-effects, termed chemotherapy-induced cognitive impairment (CICI). Another
dose-limiting chemotherapy-induced side-effect is oral and intestinal
mucositis which results in significant gastrointestinal (GIT) damage and
intestinal inflammation.
Recent interest
has been paid to neurological complications arising in patients with gut
disorders, yet little attention has been paid to the role GIT damage plays in
CICI. Our current understanding of neuronal adaptations and behavioral
consequences resulting from immune system dysregulation has paved the way for
investigation into the neuroimmunological manifestations associated with
chemotherapy.
In a clinical
setting cancer patients experience a cluster of symptoms, similar to that
manifested in cytokine-induced sickness responses.
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