Stereotactic Radiotherapy for Localized Prostate Cancer, which is Better CyberKnife or RapidArc?

We aim to compare two different stereotactic body radiation therapy (SBRT) techniques, non-isocentric CyberKnife (CK) with isocentric RapidArc (RA), more widely available treatment technique for the treatment of localized prostate cancer.

The study included six patients treated with CK then re-planned with the new version of flattening filter free (FFF) RA and CK. The prescription dose was 36.25 Gy in five fractions. The two SBRT techniques were compared by target coverage, normal tissue sparing, dose distribution parameters and delivery time.

The RA technique exhibited comparable PTV coverage and better bladder and rectum sparing at high doses. The conformity and homogeneity indices of the RA were better and statistically significant than the CK plans.

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Exceptional Therapeutic Outcome of Metastatic Neuroendocrine Tumor with Peptide Receptor Radionuclide Therapy with Brief Review of Literature

NETs are rare, heterogeneous group of neoplasm presented as chronic oncologic disease. Somatostatin analogue is the standard first line systemic therapy for mainly hormone control.

No standard second line systemic treatment is available except everolimus which has no reported complete response. PRRT is an innovative molecular targeted treatment based on theragnostic concept for well differentiated NETs.

We presented here a 63-year-old lady with grade 1 NET of rectum with lymphnodal and liver metastasis. She underwent sigmoid colostomy for bowel symptoms and started on sandostatin LAR.

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Clinical Outcomes of Grade 3 Giant Cell Tumor of Bone After Extended Intralesional Curettage

The recommended treatment of grade 3 giant cell tumor of bone (grade 3 GCTB) aims to eliminate tumor and conserve limb with extended intralesional curettage.

This treatment makes patients better function of bone and joint as usual. Even it can reduce postoperative complications and replace endoprosthesis. Still, there is limited information about the outcomes of surgical treatment and recurrence of the disease.

This study aimed to evaluate the clinical outcomes and recurrence of grade 3 GCTB with extended intralesional curettage.

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Measuring Intratumoral Metabolic Heterogeneity by Positron Emission Tomography in Cervical Cancer

Measurement of intratumoral heterogeneity by 18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography (PET) is a valuable modality, which showed correlation to response of treatment and prognosis in various malignancies.

PET-based texture analysis for tumor heterogeneity is a potential predictive factor for cervical cancer and related to lymph node metastasis, tumor volume, response of treatment, and pelvic recurrence.

Although seemed promising in utility in oncology, a plenty of methods have been used for analysis of heterogeneity which led to confusion of definitions and comparing results challenging. Further larger sized prospective studies are needed for standardized heterogeneity descriptors and clinical applications.

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Breast Cancer and Pregnancy: Experience of Maternity and Neonatology Center of Tunis-Tunisia

This document aims to identify the clinical, therapeutic, and prognostic features of this association and to provide the up-to-date management.

Our study design is retrospective based on 25 cases of pregnancy-associated breast cancer, carried out at the Maternity and Neonatology Center of Tunis over a period of 10 years, between January 2001 and December 2013.

The mean age of the patients was 35.84 years. Breast cancer was diagnosed during pregnancy in fourteen patients and after delivery in eleven patients. Pathohistological diagnosis was established by ultrasoundguided biopsy and surgical biopsy in fourteen and seven patients, respectively.

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The Hematologic Toxicity of Methotrexate in Patients with Autoimmune Disorders

The incidence of auto-immune diseases is increasing nowa- days. Despite of the development of diagnosis and management of diseases, they remained chronic diseases.

The patient’s lifespan expansion requires long-term treatment with harmful agents, such as Methotrexate or other immuno-suppressive drugs. The Methotrexate toxicities are based on the duration and cumulative dosing of drug, and the combination with other drugs.

Myelosuppression and consequent pancytopenia is the most frequent hematologic toxicity, which occur mostly later during low dose methotrexate administration. We demonstrate three cases of low dose Methotrexate toxicity in older patients with rheumatoid arthritis and psoriasis.

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Misdiagnosis of Groove Pancreatitis: A Case Report

Groove Pancreatitis (GP) is a kind of chronic pancreatitis with a clear pathological diagnosis. It’s characterized by fibrotic scarring of the gastroduodenal groove, an anatomical area near the pancreatic head, duodenum and common bile duct (CBD).

Its etiology is not clear. GP may be related to alcoholism, weight loss, biliary tract disease, pancreatic cysts and so on. Its incidence rate of GP is low and the diagnosis is difficult.

The purpose of this essay is to report a case of GP. A 56-year-old woman is admitted to hospital with painless systemic jaundice as her only symptom and the symptom aggravated in two months.

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Adjuvant Chemoradiation for Localized Gastric Adenocarcinoma: An Institutional Experience

cancer with locoregional relapse in 40% to 60%. The frequency of relapses makes regional radiotherapy an attractive possibility for adjuvant therapy. The survival benefit of adjuvant chemoradiation over surgery alone was first established by the US Intergroup 0116 study.

Between January 2010 and December 2014, 48 patients with localized gastric adenocarcinoma, managed at radiotherapy department of the national institut of oncology, they underwent adjuvant chemoradiation according the classical MacDonald regimen.

This series consisted of non-metastatic patients, 68.8% (33) males with a mean age 51 years. 20.8% (10) of patients had relapses (all distant relapse). 22 (45.8%) patients died, only 8(16.6%) patients were lost to follow up.

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