Inhibitory
effects and anti-invasive activities of trehalose liposomes (DMTreC14) composed
of L-α-dimyristoylphosphatidylcholine and
α-D-glycopyranosyl-α-D-glucopiranoside monomyristate (TreC14) on the
proliferation of human non-small cell lung carcinoma (A549) cells were examined
in vitro.
DMTreC14 with a
hydrodynamic diameter less than 100 nm, were preserved for 4 weeks. The
inhibitory effects of DMTreC14 on the proliferation of A549 cells
accompanied with apoptosis were obtained.
Enhancement of
the accumulation of DMTreC14 into A549 membranes was observed. An increase in
cellular membrane fluidity of A549 cell treated with DMTreC14 was observed on
the basis of fluorescence depolarization method.
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