
Breast cancer
frequently spreads to the skeleton and causes destructive osteolytic bone
metastases. Breast cancers express chemokine receptors, integrins, cadherins,
and bone-resorbing and bone-forming factors that contribute to the successful and
preferential spread of tumor from breast to bone.
Once breast
cancer cells arrest in bone, bone is a storehouse of a variety of cytokines and
growth factors and thus provides an extremely fertile environment for the cells
to grow.
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