Breast cancer is
the second most common cancer diagnosed worldwide, affecting approximately one
in eight women during their lifetime. Strategies
targeting the primary tumour have markedly improved, but systemic
treatments to prevent metastasis are less effective.
Breast cancer
frequently spreads to the skeleton and causes destructive osteolytic bone
metastases. Breast cancers express chemokine receptors, integrins, cadherins,
and bone-resorbing and bone-forming factors that contribute to the successful and
preferential spread of tumor from breast to bone.
Once breast
cancer cells arrest in bone, bone is a storehouse of a variety of cytokines and
growth factors and thus provides an extremely fertile environment for the cells
to grow.
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