Chemotherapy-
induced peripheral neuropathy (CIPN) is a common ailment among those taking
chemotherapeutic drugs. This condition is characterized by damage to the
nervous system that is a direct result of the medications associated with
chemotherapy.
Little is known
about the mechanisms responsible for the development of CIPN. The peripheral
toxicity involved with CIPN is specific to each chemotherapy drug class, and in
most cases, appears to be dose and duration dependent, however it can evolve
even after a single drug application.
The chemotherapy
agents Docetaxel, Paclitaxel, or Vinorelbine are used to treat breast cancer,
and often result in damage to central nervous system pain pathways, resulting
in neuropathic pain.
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