Laparoscopic Surgery for Large Ovarian Cysts- Review

Laparoscopic surgery has been increasingly applied to different gynecologic problems with excellent surgical outcome and rapid recovery.

Large ovarian cysts, a relatively common gynecologic problem, pose certain challenges to laparoscopic management.

The aim of the present study was to review published reports on laparoscopic surgery for large ovarian cysts and summarize their findings regarding patients’ selection, surgical outcome, technical methods and the final pathology report.

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Should Centralized Histopathological Review in Prostate Cancer be the Gold Standard?

To assess the potential impact of centralized histopathological review on prostate cancer management. Biopsy slides of 277 men with newly diagnosed prostate cancer between January 2010 and March 2014 from 22 centers were referred to our tertiary referral center for centralized histopathological review.

The biopsy Gleason score and D’Amico prognostic risk group were compared between those of the referring pathologists and those after assessment by a centralized histopathological review committee consisting of two specialized uro-pathologists.

Alterations in biopsy Gleason score and D’Amico prognostic risk group between referring pathologists and centralized histopathological committee were subdivided into treatment changes

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Influence of Beta Vulgaris Supplementation on the Level of Oxidative DNA Damage/Oxidative Stress in Head and Neck Cancer Patients Undergoing Radiotherapy

Because of the many controversies concerning the consumption of antioxidants during the treatment of cancer, herein we decided to ascertain whether the supplementation of Beta vulgaris (strong antioxidant) in irradiated head and neck cancer patients would influence parameters which describe oxidative stress/DNA damage and the clinical effects of therapy.

Forty one patients with head and neck cancer (T3-4 N1 M0) were divided into two subgroups: I/supplementation chips from beetroot (n=19) and II/control group (n=22). All the patients were eligible for radiotherapy.

Dische scale. Total survival times were assessed together with oxidative DNA damage on the level of the whole organism and whether the biomarkers of the damage such as 8-oxo-dG and its modified base (8-oxo-Gua) were present in urine and DNA.

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Do We Have the Right Dose? Dose Adjustments for Organ Dysfunction

Cancer patients with adequate hepatic or renal function are typically studied in clinical trials. Since most anticancer agents are cleared via hepatic or renal mechanisms, dose adjustments would be anticipated.

Yet when the drug is approved, dosing modification guidelines are often lacking for patients who have varying degrees of hepatic or renal dysfunction.

Therefore, oncologists may start therapy with an empirically-derived lower starting dose due to the perception that a patient with organ dysfunction would have poorer tolerability due to increased toxicity.

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Current Exercise Behaviors Of Breast Cancer Patients Diagnosed With Chemotherapy-induced Peripheral Neuropathy

Chemotherapy- induced peripheral neuropathy (CIPN) is a common ailment among those taking chemotherapeutic drugs. This condition is characterized by damage to the nervous system that is a direct result of the medications associated with chemotherapy.

Little is known about the mechanisms responsible for the development of CIPN. The peripheral toxicity involved with CIPN is specific to each chemotherapy drug class, and in most cases, appears to be dose and duration dependent, however it can evolve even after a single drug application.

The chemotherapy agents Docetaxel, Paclitaxel, or Vinorelbine are used to treat breast cancer, and often result in damage to central nervous system pain pathways, resulting in neuropathic pain.

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Lack of Association of Chronic Liver Disease in Patients with Oral Lichen Lanus

Lichen Planus is a chronic inflammatory disease of oral mucosa and skin. In recent years, several reports have emphasized a possible relationship between lichen planus and liver disease.

Serum glutamic oxaloacetic transaminases (SGOT), serum glutamic pyruvic transaminase (SGPT) are the most useful measures for liver cell injury. Purpose: To compare the levels of SGOT and SGPT in oral lichen planus patients and healthy controls to observe the existence of liver disease.

The sample comprised 30 oral lichen planus patients and 30 healthy controls. The blood samples were collected from both the groups and subjected to biochemical analysis for SGPT and SGOT enzymes using semi automated biochemistry analyser.

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Clinical Studies on Hormonal Status in Breast Cancer and its Impact on Quality of Life (QOL)

Breast cancer is a steroid hormone–dependent tumor. Stratification of patients according to hormone (ER/ PR) receptor status and nodal metastasis is of great therapeutic importance.

In this investigation, we could enroll 79 pre and post-menopausal breast cancer patients voluntarily. We classified these cases into four categories of the combinations of ER/PR positive, negative and mixed statuses.

Their hormone receptor status as determined by immunohistochemistry correlated with therapy regimens like chemotherapy, hormone therapy and QOL responses.

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