Protein p53 is encoded by tumor suppressor TP53, which
regulates key cellular functions such as transcription, cell cycle arrest, DNA
repair and apoptosis. Murine double minute 2 homolog (MDM2), a p53 transcribed
protein, negatively regulates p53.
A single nucleotide polymorphism (SNP) at codon 72 of TP53
(R72P, rs rs1042522) alters an amino acid, while an SNP T309G (rs2279744)
polymorphism (SNPT309G) in the promoter region of MDM2
has been reported to modulate its transcription. p53 R72P and MDM2 SNPT309G
have been reported to associate alone and or in combination with various
carcinomas.
In this study, we aimed to determine if p53 R72P and MDM2
SNPT309G polymorphism alone or in combination are associated with colon
carcinoma incidence, tumor progression and/or patient survival in Swedish
population.
No comments:
Post a Comment