Molecular Targets in Lung Cancer Therapy: A Current Review

Cancer incidence worldwide has been increasing over the years. Lung cancer (LC) is a disease with a poor prognosis once diagnosed. LC is the leading cause of death in men worldwide and the second cause of mortality in women . In Portugal, LC remains as the leading cause of deathdue cancer in men. 

LC origins from oncogenic alterations in tissues from the respiratory epithelium, namely in bronchi, bronchioles and alveoli. This cancer results from multiple morphological, molecular and genetic changes, leading to an accumulation of malignant cells. LC is mainly classified into two categories, according to its histological characteristics: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC is categorized into three different categories, namely adenocarcinoma, squamous cell carcinoma and large cell carcinoma.  Read More>>>>>>