Cancers
of the uterine corpus are the most common gynecologic cancers in the United
States with incidence and mortality increasing both in the United States of
America and globally.
Validated
biomarkers with prognostic, predictive, and/or theragnostic value will
likely play a vital role in advancing assessments of risk and guiding clinical
management decision making.
Nestin
is a class VI intermediate filament protein that was first described as a
neural stem marker and regulates the TGFβ (transforming growth factor beta)
pathway. It plays a critical role in cancer cell migration, invasion,
angiogenesis, and metastasis both in vitro and in vivo.
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