Sunday, 18 September 2016

Radio sensitization of Colon Cancer Cells Mediated by Gemcitabine through Cell Cycle Synchronization

Colon cancer is the third most common malign neoplasm worldwide. For the last 10 years, mortality rate from colon cancer has declined by 3%, and the largest drops occurred in adults aged 65 and olde. This decline can be attributed to the increase of screening, which detects and allows the removal of precancerous polyps.

Cell Cycle Synchronization

In contrast, rates increased during this time period among adults younger than 50 years. In Brazil this type of cancer is ranked in third place among other incidences of cancer and it is the third cause of deaths from cancer. In general, the most affected age range is of 40-70 years. The conditions associated to increase a risk to develop colon cancer include a personal history of colorectal cancer or adenomatous polyps.

A personal history of inflammatory bowel disease (ulcerative colitis or Crohn’s disease); a strong family history of colorectal cancer or polyps; a known family history of a hereditary colorectal cancer syndrome such as familial adenomatous polyposis (FAP) or hereditary non-polyposis colon cancer.


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