Since 1959 the American Joint Committee on Cancer (AJCC) TNM
system has been used to stage breast cancer. Since then, the TNM has helped
clinicians in deciding the better treatment for each patient.
Periodically revisions have been made to this classification
with the aim of keeping a relationship between the disease
extent and the prognosis. However, when we talk about breast cancer, the TNM is not always
enough.Several publications in the last years report that there are other
predictive factors that influence the prognosis, measured by the overall
survival or the DFS (disease-free survival), as much as the TNM stage does.
Some authors claim that important factors as primary tumor
histologic grade and biologic tumor markers should be included in the AJCC
system.
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